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Research topics

1.            Survival analysis in cancer. Our main goal is to develop tools to link cancer survival and gene expression or mutations based mono- or multigenic prognostic signatures. We develop online accessible tools for automated evaluation. We participate in international collaborations aiming the validation of identified prognostic and predictive signatures.

2.            Cell culture studies. We strive to identify resistance biomarkers of targeted therapy agents used in oncology. We utilize cell culture models to inhibit and/or silence target genes. Then, the magnitude of response to chemo- and targeted therapy is evaluated and the phenotype changes are characterized.

3.            Linking genotype to clinical response. We process next generation sequencing data generated by the TCGA consortia. We process the entire gene sequence and the expression of all genes in multiple thousand patients from various solid tumors. By linking different levels of data we can directly link a genotype change to genes with an effect on clinical outcome.

 

International collaborations

  • Igor Roninson, University of South Carolina, USA
  • Saraswati Sukumar, John Hopkins, Baltimore, USA
  • Pusztai Lajos, Yale Cancer Center, New Haven, USA
  • Sophia Chernikova, Stanford University, USA
  • Yatrik Shah, University of Michigan, USA
  • Mathieu Lupien, University of Toronto, Canada
  • Libero Santarpia, Humanitas Clinical and Research Center, Italy
  • Reinhold Schäfer, Charité Berlin, Germany
  • Jan Budczies, Charité Berlin, Germany
  • Thomas Karn, University of Frankfurt, Germany
  • Irina Nazarenko, University of Freiburg, Germany
  • Antonio Postigo, ICREA, Spain
  • Luca Magnani, Imperial College, London, UK
  • Michael Lisanti, University of Manchester, UK
  • Simak Ali, Imperial College, London, UK
  • Casanova Emilio, Medical University of Vienna, Austria
  • Baharia Mograbi, University of Nice-Sophia Antipolis, France
  • Pascale Cohen, University of Lyon, France
  • Khalid Khabar, King Faisal Research Centre, Riyadh, Saudi Arabia
  • Takayuki Iwamoto, Okayama University, Japan
  • Yong Han, Peking University, China

 

Group leader

Dr. Balázs Győrffy, Doctor of Science, Hungarian Academy of Sciences

Personal homepage:  http://gyer1-6.sote.hu/gyorffy

Publications:  http://scholar.google.com/citations?hl=hu&user=KUKTJFYAAAAJ

 

Lab members

Ádám Nagy, PhD fellow

Péter Herman, bioinformatician

Lőrinc Pongor, PhD fellow

 

Graduate students

  • Csonka Gábor, MSc student (PPKE)
  • Bán Bence, MD student (SE)
  • Bartha Áron, MD student (SE)
  • Szoljárt Richárd, MSc student (PPKE)
  • Hudacsek Viktória Vivien, MSc student (BME)
  • Winter Dorottya, BSc student (PPKE)
  • Keömley-Horváth Bence Márk, BSc student (PPKE)
  • Aszódi Boglárka, BSc student (PPKE)