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Systems Biology of Reproduction Research Group

Research project

The Systems Biology of Reproduction Research Group studies the obstetrical, biological, immunological, pathological and systems biological aspects of the ‘Great Obstetrical Syndromes’. The importance of the topic is supported by the fact that 70% of pregnancies and 15% of clinically recognized pregnancies end with miscarriage, and 25% of pregnant women have obstetrical syndromes that may have severe impact on the health of both mother and child. The research group studies and characterizes signal transduction pathways that may play key role in the development of miscarriages and obstetrical syndromes. The focus is on the systems biological investigation of the complex and overlapping dysregulation of maternal-fetal immuntolerance, trophoblast invasion and differentiation. Besides describing molecular pathways and signaling networks of pregnancy complications, our investigations may also reveal novel biomarkers and drug targets.

Scientific collaborations

  • Hungarian Academy of Sciences, Research Centre for Natural Sciences
  • Semmelweis University, First Department of Pathology and Experimental Cancer Research; Department of Genetics, Cell- and Immunobiology; Maternity Clinic
  • Eötvös Loránd University, Institute of Biology
  • Hungarian Academy of Sciences, Biological Research Centre, Institute of Genetics
  • Perinatology Research Branch, National Institutes of Health (Detroit, MI, USA)
  • Wayne State University (Detroit, MI, USA)
  • University of Southern California (Los Angeles, CA, USA)
  • Zymo Research Corporation (Irvine, CA, USA)
  • Ben Gurion University (Beer Sheva, Israel)
  • University of Basel (Basel, Switzerland)

Teaching activity

Postgradual training:

  • Semmelweis University – Chapters from the immunobiology of pregnancy
  • Eötvös Loránd University – The systems biological view of the immunology of pregnancy

PhD topic:

  • Semmelweis University, Clinical Medicine Doctoral School – Pathomechanisms, early prediction and diagnosis of the Great Obstetrical Syndromes

Media presence




Principal investigator

Nándor Gábor Than, MD PhD, senior research fellow

Research group

Amanda Demeter MSc, PhD student

Zsolt Gelencsér PhD, informatician

Szabolcs Hetey MSc, research fellow

Kata Juhász PhD, research fellow

Gyöngyi Kenesi MSc, biologist

János Pálhalmi PhD, senior research fellow

Andrea Papp-Balogh PhD, research fellow

Anett Szécsi MSc, biologist

Nikolett Szénási MSc, PhD student