Department of Biological Nanochemistry
Attila Bóta, Dr.
Phone: +36 1 438 1100 /449, 277
Mrs. Szilvia Berényi, Mrs. Éva Pfeifer, Kocsisné Mr. Tibor Kremmer, Prof. Mr. Sándor Kristyán, Ph.D. Mr. András Lőrincz Mrs. Judith Mihály, Ph.D. Mrs. Lívia Naszályi, Nagy, Ph.D. Mr. Csaba Németh Mr. Marcell Pálmai Mr. Balázs Söptei Mr. Zoltán Varga, Ph.D. Mr. András, Ferenc Wacha
The primary task of the Department of Biological Nanochemistry is the preparation and characterisation of nanosized systems for medical applications.
The wide-ranging activities of the department connect the fields of chemistry, physics and biology. Our activities include the preparation and modification of nanostructures, their characterisation from the atomic level to the µm range, optimisation for biological and medical applications, and toxicity studies.
Primary research areas
- Preparation and surface modification of organic and inorganic nanosystems.
- Investigation of the structure and dynamics of model membrane systems (uni- and multilamellar vesicles), and their interactions with drugs and other molecules of biological importance
- Development of nanostructures for the targeted delivery of drugs and sensor molecules.
- Investigation of the biological activity and toxicity of the nanosystems prepared.
- Separation and characterization of real biological vesicle systems
Key topics in the research expert teams of the Department of Biological Nanochemistry
- Characterization of nanostructures by high quality small angle X-ray scattering data obtained at synchrotron stations
- Software developing for data evaluation in the field of small angle X-ray and neutron scattering and diffraction
- Surface and local morphology of freeze-fractured lyotrop systems
- In situ structural and morphological characterization of sheered lyotrop systems
- Comparative (thermodynamic, structural rheological) studies of hyaluronan acids and their derivatives
- Detailed structural description and modifications of sterically stabilized vesicles/liposomes
- Separation and purification of biological membrane constituents
- Surface modification of core-shell nanoparticles by using squaric acid
- Preparation and surface modification of CdS, CdTe, CdSe quantum dots
- Computer simulations of self assembled systems consisting of hydrated amphipatic molecules (e.g. lipids) and drugs
Practise and projects at synchrotron stations and neutron sources
Syncrotron stations for X-ray scattering and diffraction:
- Synchrotron Hamburg, DESY/HASYLAB (Germany)
- Synchrotron Berlin, BESSY (Germany)
- European Synchrotron Radiation Facility, ESRF, Grenoble (France)
- Advanced Photon Source/Argonne National Laboratory, APS, Chicago (USA)
- Advenced Light Source/Lawrence Berkeley National Laboratory, ALS, San Francisco (USA)
- Budapest Neutron Centre, Budapest (Hungary)
- Neutron Research Reactor München, FRM-II, Garching (Germany)
- Institute of Max von Laue- Paul Langevin, ILL, Grenoble, (France)
- Differential scanning calorimeter (µDSC3, Setaram)
- Freeze-fracture apparatus (Balzers AG.)
- Rheometer (Haake, RheoStress1)
- Compact small- and wide-angle camera with position sensitive detectors, X-ray generator (Anton Paar, HECUS, Seifert)
- Infra spectrometer (Bomem)
- FT-Infra microscope (Varian FTS-7000, UMA-600)
- FT-Raman spectrometer (Biorad/Digilet)
- FT-IR spectrometer with ATR equipment (Varian FTS 2000)
- UV-VIS spectrometer (Agilent 8453)
- HPLC system (Jasco)
- Laminar box
- CO2incubator for cell lines
- Complete colloid-chemistry lab for synthesis, separation and purification
- Wigner Research Centre for Physics, Hungarian Academy of Sciences, Department of Neutron Spectroscopy
- Biological Research Centre, Hungarian Academy of Sciences, Institute of Plant Biology, Laboratory of Photosynthetic Membranes
- Institute of Enzymology, Hungarian Academy of Sciences
- Budapest Universityy of Technology and Economics, Department of Physical Chemistry and Materials Science
- Semmelweis University, Department of Medical Biochemistry, Haemostasis Research Division
- Semmelweis University, Institute of Medical Microbiology
- National Institute of Oncology Department of Biochemistry,
- Vichem Chemie Ltd.
- KPS Medical Biotechnologies Healthcare Services Ltd.
- Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics
- Faculty of Science, Eötvös Loránd University