Chemical Biology Research Group

Homepage of the research group.

We are part of the COST EpiChemBio Action.

Publications

Total of 47 publications in 2013 – 2016

2016

Söveges, B.; Imre, T.; Szende, T.; Póti, Á. L.; Cserép, G. B.; Hegedűs, T.; Kele, P.; Németh, K., Systematic study of protein labeling by fluorogenic probes using cysteine targeting vinyl sulfone-cyclooctyne tags, Org. Biomol. Chem. 2016, doi: 10.1039/c6ob00810k.

Kozma, E.; Nikić, I.; Varga, B. R.; Aramburu, I. V.; Kang, J. H.; Fackler, O. T.; Lemke E. A.; Kele, P., Hydrophilic trans-Cyclooctenylated Non-Canonical Amino Acids for Fast Intracellular Protein Labeling, ChemBioChem 2016, doi: 10.1002/cbic.201600284.

Knorr, G.; Kozma, E.; Herner, A.; Lemke, E. A.; Kele, P., New, red-emitting tetrazine-phenoxazine fluorogenic labels for live-cell intracellular bioorthogonal labeling schemes, Chem. Eur. J. 2016, doi: 10.1002/chem.201600590.

Demeter, O.; Fodor, E. A.; Kállay, M.; Mező, G.; Németh, K.; Szabó, P. T.; Kele, P., A Double-Clicking Bis-Azide Fluorogenic Dye for Bioorthogonal Self-Labeling Peptide Tags, Chem. Eur. J. 2016, 22, 6382-6388.

Eördögh, Á.; Steinmeyer, J.; Peewasan, K.; Schepers, U.; Wagenknecht, H-A.; Kele, P., Polarity sensitive bioorthogonally applicable far-red emitting labels for postsynthetic nucleic acid labeling by copper-catalyzed and copper-free cycloaddition, Bioconjugate Chem. 2016, 27(2), 457-464.

2015

Cserép, G. B.; Herner, A.; Kele, P., Bioorthogonal fluorescent labels: a review on combined forces, Methods Appl. Fluoresc. 2015, 3(4), 042001.

Domonkos, C.; Zsila, F.; Fitos, I.; Visy, J.; Kassai, R.; Bálint, B.; Kotschy, A., Synthesis and serum protein binding of novel ring-substituted harmine derivatives, RSC Adv. 2015, 5, 53809-53818.

Cserép, G. B.; Demeter, O.; Bätzner, E.; Kállay, M.; Wagenknecht, H-A.; Kele, P., Synthesis and Evaluation of Nicotinic Acid Derived Tetrazines for Bioorthogonal Labeling, Synthesis 2015, 47, 2738-2744.

Castillo, G.; Pribransky, K.; Mező, G.; Kocsis, L.; Csámpai, A.; Németh, K.; Keresztes, Zs.; Hianik, T., Electrochemical and Photometric Detection of Plasmin by Specific Peptide Substrate, Electroanalysis 2015, 27(3), 789-798.

Huber, M. C.; Schreiber, A.; von Olshausen, P.; Varga, B. R.; Kretz, O.; Joch, B.; Barnert, S.; Schubert, R.; Eimer, S.; Kele, P.; Schiller, S. M., Designer amphiphilic proteins as building blocks for the intracellular formation of organelle-like compartments, Nat. Mater. 2015, 14, 125-132.

2014

Domonkos, C.; Fitos, I.; Visy, J.; Zsila, F., Role of the conformational flexibility of evodiamine in its binding to protein hosts: a comparative spectroscopic and molecular modeling evaluation with rutaecarpine, Phys. Chem. Chem. Phys. 2014, 16(41), 22632-22642.

Németh, K.; Domonkos, C.; Sarnyai, V.; Szemán, J.; Jicsinszky, L.; Szente, L.; Visy, J., Cationic permethylated 6-monoamino-6-monodeoxy-β-cyclodextrin as chiral selector of dansylated amino acids in capillary electrophoresis, J. Pharm. Biomed. Anal. 2014, 99, 16-21.

Stubinitzky, C.; Cserép, G. B.; Bätzner, E.; Kele, P.; Wagenknecht, H-A., 2’-Deoxyuridine Conjugated with a Reactive Monobenzocyclooctyne as a DNA Building Block for Copper-Free Click-type Postsynthetic Modification of DNA, Chem. Commun. 2014, 50, 11218-11221.

Herner, A.; Girona, G. E.; Nikić, I.; Kállay, M.; Lemke, E. A.; Kele, P., New Generation of Bioorthogonally Applicable Fluorogenic Dyes with Visible Excitations and Large Stokes Shifts, Bioconjugate Chem. 2014, 25(7), 1370-1374.

Cserép, G. B.; Baranyai, Zs.; Komáromy, D.; Horváti, K.; Bősze, Sz.; Kele, P., Fluorogenic tagging of peptides via Cys residues using thiol-specific vinyl sulfone affinity tags, Tetrahedron 2014, 70, 5961-5965.

Bobály, B.; Tóth, E.; Drahos, L.; Zsila, F.; Visy, J.; Fekete, J.; Vékey, K., Influence of acid-induced conformational variability on protein separation in reversed phase high performance liquid chromatography, J. Chromatogr. A 2014, 1325, 155-162.

2013

Cserép, G. B.; Herner, A.; Wolfbeis, O. S.; Kele, P., Tyrosine specific sequential labeling of proteins, Bioorg. Med. Chem. Lett. 2013, 23, 5776-5778.

Herner, A.; Nikić, I.; Kállay, M.; Lemke, E. A.; Kele, P., A new family of bioorthogonally applicable fluorogenic labels, Org. Biomol. Chem. 2013, 11, 3297-3306.

Cserép, G. B.; Enyedi, K. N.; Demeter, A.; Mező, G.; Kele, P., NIR Mega-Stokes Fluorophores for Bioorthogonal Labeling and Energy Transfer Systems – An Efficient Quencher for Daunomycin, Chem. Asian J. 2013, 8, 494-502.

Kele, P.; Li, X.; Duerkop, A., New luminescent ruthenium probes for detection of diacetyl, Microchem. J. 2013, 108, 156-160.

Educational activity

  • Introduction to modern biology (Eötvös University) – fall semester
  • Introduction to bioorthogonal chemistry (Eötvös University) – spring semester
  • Introduction to molecular recognition (Eötvös University) – spring semester

Collaborations

  • Edward Lemke, EMBL, Heidelberg, Germany
  • Hans-Achim Wagenknecht, Karlsruhe Institute of Technology, Karlsruhe, Germany
  • Stefan Schiller, University of Freiburg, Freiburg, Germany
  • Shixin Ye-Lehmann, ENS-Paris, Paris, France

Leader

Péter Kele

Members

2018-06-23T08:37:32+00:00 2018. April 11.|Research Groups|
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